期刊
PLACENTA
卷 33, 期 4, 页码 233-243出版社
W B SAUNDERS CO LTD
DOI: 10.1016/j.placenta.2011.11.026
关键词
Hemochorial placentation; Invasive trophoblast; Metrial gland; Uterine vascular remodeling
资金
- American Heart Association
- Lalor Foundation
- Canadian Institute for Health Research
- National Institutes of Health [HD20676, HD049503, HD055523, HD060115]
The rat possesses hemochorial placentation with deep intrauterine trophoblast cell invasion and trophoblast-directed uterine spiral artery remodeling; features shared with human placentation. Recognition of these similarities spurred the establishment of in vitro and in vivo research methods using the rat as an animal model to address mechanistic questions regarding development of the hemochorial placenta. The purpose of this review is to provide the requisite background to help move the rat to the forefront in placentation research. (C) 2011 Elsevier Ltd. All rights reserved.
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