期刊
PLACENTA
卷 33, 期 2, 页码 132-134出版社
W B SAUNDERS CO LTD
DOI: 10.1016/j.placenta.2011.11.027
关键词
Preeclampsia; Fatty acid oxidation; Long-chain 3-hydroxyacyl-CoA; Medium-chain acyl-CoA dehydrogenase
资金
- Consejeria de Salud, Junta de Andalucia [0269/05.2005]
- Carlos III Health Institute [CP08/00106]
- Spanish Ministry of Science and Innovation [SAF2009-11282]
- [FP7-PEOPLE-2009-RG (PIRG06-GA-2009-25369)]
Preeclampsia is a leading cause of maternal and fetal morbidity and mortality in high and low-income countries. The aetiology of preeclampsia is multifactorial and remains obscure. Some evidences suggest that altered placental fatty acid oxidation might play a role in the pathogenesis of preeclampsia. To reveal if placental fatty acid oxidation is reduced in preeclampsia, we evaluate the expression levels of enzymes of mitochondrial fatty acid oxidation using quantitative Real-time PCR and the fatty acid oxidation rate in placental explants. We found that long-chain 3-hydroxyacyl-CoA dehydrogenase levels and fatty acid oxidation capacity were significantly reduced in placentas from women with preeclampsia. (C) 2011 Elsevier Ltd. All rights reserved.
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