期刊
PIGMENT CELL & MELANOMA RESEARCH
卷 25, 期 2, 页码 -出版社
WILEY
DOI: 10.1111/j.1755-148X.2012.00976.x
关键词
melanoma; somatic mutation; sequencing
资金
- National Human Genome Research Institute, National Institutes of Health, USA
Melanoma, the most aggressive form of skin cancer, has increased in incidence more rapidly than any other cancer. The completion of the human genome project and advancements in genomics technologies has allowed us to investigate genetic alterations of melanoma at a scale and depth that is unprecedented. Here, we survey the history of the different approaches taken to understand the genomics of melanoma from early candidate genes, to gene families, to genome-wide studies. The new era of whole-exome and whole-genome sequencing has paved the way for an in-depth understanding of melanoma biology, identification of new therapeutic targets, and development of novel personalized therapies for melanoma.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据