期刊
PIGMENT CELL & MELANOMA RESEARCH
卷 24, 期 6, 页码 1112-1115出版社
WILEY
DOI: 10.1111/j.1755-148X.2011.00919.x
关键词
PHGDH; serine; biosynthesis; cancer; metabolism; 3-phosphoglycerate; glycolysis
The metabolic requirements of cancer cells differ from that of their normal counterparts. To support their proliferation, cancer cells switch to a fermentative metabolism that is thought to support biomass production. Instances where metabolic enzymes promote tumorigenesis remain rare. However, an enzyme involved in the de novo synthesis of serine, 3-phosphoglycerate dehydrogenase (PHGDH), was recently identified as a putative oncogene. The potential mechanisms by which PHGDH promotes cancer are discussed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据