期刊
PIGMENT CELL & MELANOMA RESEARCH
卷 23, 期 3, 页码 375-384出版社
WILEY
DOI: 10.1111/j.1755-148X.2010.00703.x
关键词
vitiligo; segmental vitiligo; etiopathogenesis; histopathology; melanocyte; halo nevi
资金
- Fund for Scientific Research-Flanders (FWO Vlaanderen) [G.0161.07]
- Dutch Cancer Society [UVA2006-3606]
P>Segmental vitiligo is often ascribed to the neurogenic theory of melanocyte destruction, although data about the initial etiopathological events are scarce. Clinical, histopathological and T-cell phenotypic analyses were performed during the early onset of a segmental vitiligo lesion in a patient with associated halo nevi. Histopathological analysis revealed a lymphocytic infiltrate, mainly composed of CD8+ T-cells and some CD4+ T-cells around the dermo-epidermal junction. Flow cytometry analysis of resident T-cells revealed a clear enrichment of pro-inflammatory IFN-gamma producing CD8+ T-cells in lesional skin compared to the non-lesional skin. Using human leukocyte antigen-peptide tetramers (MART-1, tyrosinase, gp100), increased numbers of T cells, recognizing melanocyte antigens were found in segmental vitiligo lesional skin, as compared with the non-lesional skin and the blood. Our findings indicate that a CD8+ melanocyte specific T cell-mediated immune response, as observed in generalized vitiligo, also plays a role in segmental vitiligo with associated halo nevi.
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