期刊
PHYTOTHERAPY RESEARCH
卷 29, 期 2, 页码 159-166出版社
WILEY
DOI: 10.1002/ptr.5240
关键词
metabolomics; traditional medicine; Western medicine; drug discovery; systems biology; biomarkers
资金
- Key Program of Natural Science Foundation of State [90709019, 81173500, 81373930, 81302905, 81102556, 81202639]
- National Key Technology Research and Development Program of the Ministry of Science and Technology of China [2011BAI03B03, 2011BAI03B06, 2011BAI03B08]
- National Key Subject of Drug Innovation [2009ZX09502-005]
- Foundation of Heilongjiang University of Chinese Medicine [201209]
Metabolomics provides an opportunity to develop the systematic analysis of the metabolites and has been applied to discovering biomarkers and perturbed pathways which can clarify the action mechanism of traditional Chinese medicines (TCM). TCM is a comprehensive system of medical practice that has been used to diagnose, treat and prevent illnesses more than 3000years. Metabolomics represents a powerful approach that provides a dynamic picture of the phenotype of biosystems through the study of endogenous metabolites, and its methods resemble those of TCM. Recently, metabolomics tools have been used for facilitating interactional effects of both Western medicine and TCM. We describe a protocol for investigating how metabolomics can be used to open up dialogue' between Chinese and Western medicine, and facilitate lead compound discovery and development from TCM. Metabolomics will bridge the cultural gap between TCM and Western medicine and improve development of integrative medicine, and maximally benefiting the human. Copyright (c) 2014 John Wiley & Sons, Ltd.
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