Lipid-Lowering Effects of Curcumin in Patients with Metabolic Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial

Human studies of curcumin extract on lipid-lowering effect have not been completely investigated and have had controversy results. This study tested the effect of daily curcumin extract for 12weeks on weight, glucose, and lipid profiles in patients with metabolic syndrome. Sixty-five patients were randomized into two groups; 33 patients taking curcumin extract capsule (630mg thrice daily) and 32 patients taking a placebo capsule thrice daily for 12weeks. At 12weeks after the curcumin extract consumption, the level of high-density lipoprotein cholesterol (HDL-C) significantly increased from 40.96 +/- 8.59 to 43.76 +/- 2.79mg/dL (p<0.05), and the level of low-density lipoprotein cholesterol (LDL) was significantly reduced (120.55 +/- 36.81 to 106.51 +/- 25.02mg/dL, p<0.05). The triglyceride-lowering effect, a reduction of 65mg/dL, was also found in this study. In subgroups analysis, the consumption of curcumin may have a lowering cholesterol effect in male patients and an increasing HDL-C effect in female patients, both of which result in a decrease of T-Chol/HDL-C ratio. The intake of the curcumin extract of 1890mg/day for 12weeks was associated with lipid-lowering effect but did not improve weight and glucose homeostasis in the patients with metabolic syndrome. Daily curcumin consumption may be an alternative choice to modify cholesterol-related parameters, especially in metabolic syndrome patients. Copyright (c) 2014 John Wiley & Sons, Ltd.