期刊
PHYTOTHERAPY RESEARCH
卷 27, 期 11, 页码 1646-1657出版社
WILEY-BLACKWELL
DOI: 10.1002/ptr.4915
关键词
nerunjil; streptozotocin; thermal analgesia; allodynia; oxidative stress; cytokines
资金
- Department of Science and Technology, New Delhi [VI-D & P/271/08-09/TDT]
The present study aimed to evaluate standardized aqueous Tribulus terristris (nerunjil) extract on the pain threshold response in streptozotocin (STZ)-induced diabetic neuropathic pain model in rats. After a single injection of STZ (40mg/kg; i.p.), Wistar male rats were tested by the thermal and chemical-induced pain models. Diabetic rats exhibited significant hyperalgesia, and these rats were left untreated for the first four weeks. Thereafter, treatment was initiated and continued up to week-8. All the rats except the vehicle-treated group received insulin 5IU/kg/day to maintain plasma glucose levels. Treatment with nerunjil (100 and 300mg/kg; p.o.) for 4weeks significantly attenuated the nociception in behavioural models. Nerunjil also inhibited the tumour necrosis factor- and interleukin-1 beta levels. The effect of nerunjil (300mg/kg) is comparable to the standard drug Pregabalin (100mg/kg). Nerunjil increased the superoxide dismutase, catalase, glutathione peroxidase, reduced glutathione, and decreased the lipid peroxide levels in dose-dependent manner. Insulin alone-treated rats failed to attenuate hyperalgesic response. In comparison to insulin alone-treated rats, nerunjil exhibited significant increase in the pain threshold response. It could be concluded that in controlled diabetic states, nerunjil attenuated the neuropathic pain through modulation of oxidative stress and inflammatory cytokine release. Copyright (c) 2012 John Wiley & Sons, Ltd.
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