期刊
PHYTOTHERAPY RESEARCH
卷 26, 期 12, 页码 1817-1822出版社
WILEY
DOI: 10.1002/ptr.4657
关键词
chamomile; Matricaria recutita L.; metalloprotease; elastase; gastritis; flavonoids
资金
- FSE, Regione Lombardia
- Universita degli Studi di Milano
- Bonomelli s.r.l.
This study investigated whether the antiinflammatory effect of chamomile infusion at gastric level could be ascribed to the inhibition of metalloproteinase-9 and elastase. The infusions from capitula and sifted flowers (2501500 mu g/mL) and individual flavonoids (10 mu m) were tested on phorbol 12-myristate 13-acetate-stimulated AGS cells and human neutrophil elastase. The results indicate that the antiinflammatory activity associated with chamomile infusions from both the capitula and sifted flowers is most likely due to the inhibition of neutrophil elastase and gastric metalloproteinase-9 activity and secretion; the inhibition occurring in a concentration dependent manner. The promoter activity was inhibited as well and the decrease of metalloproteinase-9 expression was found to be associated with the inhibition of NF-kappa B driven transcription. The results further indicate that the flavonoid-7-glycosides, major constituents of chamomile flowers, may be responsible for the antiinflammatory action of the chamomile infusion observed here. Copyright (c) 2012 John Wiley & Sons, Ltd.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据