期刊
PHYTOTHERAPY RESEARCH
卷 26, 期 11, 页码 1656-1660出版社
WILEY-BLACKWELL
DOI: 10.1002/ptr.4626
关键词
Peltiphyllum peltatum; Saxifragaceae; antioxidant; alpha-glucosidase; 11-O-galloylbergenin; gallates; catechins
The antioxidant, anti-alpha-glucosidase and anticholinesterase effects of the alcohol extract of fresh underground rhizomes of Peltiphyllum peltatum were studied. A potent antioxidant activity accompanied by a selective alpha-glucosidase effect was observed for the crude extract. Further activity-guided fractionation (petroleum ether, chloroform, ethyl acetate, n-butanol and water) resulted in the identification of the ethyl acetate fraction with the highest antioxidant effect. Gallic acid, methyl-3-O-methyl gallate, catechin, gallocatechin, bergenin and 11-O-galloylbergenin were isolated from the ethyl acetate fraction. While all the isolated compounds did show a variable degree of radical scavenging effect, 11-O-galloylbergenin was identified as the selective alpha-glucosidase inhibitor. The isolation, structural elucidation and biological effects of these compounds are discussed. Copyright (c) 2012 John Wiley & Sons, Ltd.
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