期刊
PHYTOTHERAPY RESEARCH
卷 27, 期 1, 页码 148-151出版社
WILEY-BLACKWELL
DOI: 10.1002/ptr.4694
关键词
Eisenia bicyclis; phlorotannins; pancreatic lipase inhibitor; 7-phloroeckol; fucofuroeckol A
资金
- Basic Science Research Program of the National Research Foundation of Korea (NRF)
- Ministry of Education, Science and Technology [2010-0022783]
- National Research Foundation of Korea [2010-0022783] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Pancreatic lipase is a potential therapeutic target for the treatment of diet-induced obesity in humans. In an ongoing search for new pancreatic lipase inhibitors from natural sources, a methanolic extract of marine brown algae, Eisenia bicyclis, showed a significant inhibitory effect against pancreatic lipase. Bioassay-guided isolation of this methanolic extract using a pancreatic lipase inhibitory assay led to the isolation and identification of six known phlorotannins: eckol (1), fucofuroeckol A (2), 7-phloroeckol (3), dioxindehydroeckol (4), phlorofucofuroeckol A (5), and dieckol (6). The structures were established on the basis of nuclear magnetic resonance and mass spectrometry spectroscopic data interpretation. Among the isolated phloroglucinol polymers, compounds 2 and 3 showed potent inhibitory effects on pancreatic lipase with IC50 values ranging from 37.2 +/- 2.3 to 12.7 +/- 1.0 mu M, respectively. Copyright (C) 2012 John Wiley & Sons, Ltd.
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