期刊
PHYTOTHERAPY RESEARCH
卷 27, 期 5, 页码 699-704出版社
WILEY
DOI: 10.1002/ptr.4777
关键词
Phoenix dactylifera L; epicarp; Arecaceae; new flavones; antidiabetic activity
The new natural flavonoid compounds diosmetin 7-O--L-arabinofuranosyl (12) -D-apiofuranoside (1) and diosmetin 7-O--D-apiofuranoside (2) were isolated from the acetone extract of date fruits epicarp belonging to family Arecaceae (Palmae). Elucidation of their chemical structures was determined by different spectroscopic methods in addition to the chemical and physical methods of analysis. These compounds were assessed for their biological activity on alloxan diabetic rats. A dose of 1.5ml of (1) and (2) suspensions/100 gm b. wt were orally administrated to alloxan diabetic rats for 30days. The treatment of diabetic rats with these compounds resulted in marked improvement of the different biochemical results, i.e. the serum glucose level (highly significant, from 330+5.5mg/dL to 140+1.2mg/dL) treated with (1); liver functions markedly developed both by AST and ALT levels, (reduced significantly from 68.3+4.8/L to 54+5.5/L and from 61.0+3.6/L to 40.1+3.6/L, respectively) treated with (2), accompanying with mild decrease in both cholesterol and triglycerides levels with (1) or (2). Decrease of TBARS level was observed in whole blood when treated with (1) or (2), while levels of glutathione peroxidase and superoxide dismutase were increased in liver. Serum testosterone level was highly significantly increased (from 705.1+3.6mg/100ml to 720+4.7mg/100ml), total acid phosphatase and prostate acid phosphatase activities were highly significantly decreased (from 16.9+0.28/L to 10.7+1.2/L and from 9.7+0.7/L to 6.5+1/L, respectively) for compound (1). Copyright (c) 2012 John Wiley & Sons, Ltd.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据