期刊
PHYTOTHERAPY RESEARCH
卷 26, 期 9, 页码 1265-1271出版社
WILEY
DOI: 10.1002/ptr.3729
关键词
thiacremonone; garlic extract including bioflavonoids; antiobesity effect; serum enzyme; PPAR
资金
- Korea Research Foundation
- South Korean government [R13-2008-001-00000-00, 2010-0019306]
- Priority Research Centers Program [2009-0093824]
- National Research Foundation of Korea [2009-0085906]
- National Research Foundation of Korea [2009-0085906] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Garlic is widely used as a spice. Garlic extracts exert anticancer and antiinflammatory effects, but its antiobesity efficacy studies have produced conflicting results. The antiobesity effects of thiacremonone, a sulfur compound isolated from garlic, was evaluated in obese db/db mice. Thiacremonone was orally administrated to mice for 3?weeks. The thiacremonone-treated db/db mice showed a loss of body weight and decrease in blood triglyceride and glucose levels compared with the control mice. Histological analysis further revealed that thiacremonone significantly decreased lipid accumulation in the fatty livers of treated db/db mice. It was observed that GLUT-4 expression and glucose uptake were up-regulated by thiacremonone in 3T3-L1 adipocytes. Thiacremonone treatment also suppressed expression levels of acetyl-CoA carboxylase (ACC) and fatty acid synthase (FAS), which are involved in lipid metabolism, in the liver of db/db mice. In addition, thiacremonone enhanced peroxisome proliferator-activated receptor ? (PPAR?) expression in the fatty liver. Taken together, these results suggest that thiacremonone may play a vital role in improving the management of obesity and related metabolic syndromes via inhibition of lipid accumulation. Copyright (C) 2012 John Wiley & Sons, Ltd.
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