期刊
PHYTOTHERAPY RESEARCH
卷 27, 期 2, 页码 236-243出版社
WILEY
DOI: 10.1002/ptr.4681
关键词
Myrtaceae plant; insulin resistance; glucose uptake; wax apple; vescalagin
资金
- National Science Council, Taiwan [NSC-97-2313-B-214-002-MY3]
This study investigated the glucose uptake activity of the water extracts from the leaves and fruit of edible Myrtaceae plants, including guava (Psidium guajava Linn.), wax apples [Syzygium samarangense (Blume) Merr. and L.M. Perry], Pu-Tau [Syzygium jambo (L.) Alston], and Kan-Shi Pu-Tau (Syzygium cumini Linn.) in FL83B mouse hepatocytes. The fluorescent dye 2-(n-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose was used to estimate the uptake ability of the cells. Glucose uptake test showed that pink wax apple fruit extract (PWFE) exhibits the highest glucose uptake activity, at an increment of 21% in the insulin-resistant FL83B mouse hepatocytes as compared with the TNF--treated control group. Vescalagin was isolated using column chromatography of PWFE. This compound, at the concentration of 6.25 mu g/mL, exhibits the same glucose uptake improvement in insulin-resistant cells as PWFE at a 100-mu g/mL dose. We postulate that vescalagin is an active component in PWFE that may alleviate the insulin resistance in mouse hepatocytes. Copyright (c) 2012 John Wiley & Sons, Ltd.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据