期刊
PHYTOTHERAPY RESEARCH
卷 25, 期 11, 页码 1629-1635出版社
WILEY
DOI: 10.1002/ptr.3469
关键词
flavonoid; 3T3-L1 preadipocyte; isoquercitrin; Wnt/beta-catenin pathway
资金
- National Research Foundation (NRF)
- Ministry of Education, Science and Technology of Korea government (MEST) (Translational Research Center for Protein Function Control) [2010-0001919, 2010-0026844]
- Enprani Co
- Incheon
- Ministry of Knowledge Economy (through the Korea Research Institute of Chemical Technology) [SI-095]
- National Research Foundation of Korea [2010-0026844] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Obesity, which is related to metabolic syndrome and is associated with liver disease, represents an epidemic problem demanding effective therapeutic strategies. Evidence shows that the Wnt/beta-catenin pathway is closely associated with obesity and that small molecules regulating the Wnt/beta-catenin pathway can potentially control adipogenesis related to obesity. Eleven plant extracts activating the Wnt/beta-catenin pathway were screened by using HEK 293-TOP cells retaining the Wnt/beta-catenin signaling reporter gene. An extract of Persicaria hydropiper ( L.) Spach was found to activate Wnt/beta-catenin signaling. P. hydropiper is grown worldwide in temperate climates and is found widely in Southeast Asia. The P. hydropiper extract inhibited the differentiation of adipocyte 3T3-L1 cells. Isoquercitrin and isorhamnetin, constituents of P. hydropiper, also activated Wnt/beta-catenin signaling and suppressed the differentiation of 3T3-L1 cells. These results indicate that isoquercitrin in P. hydropiper suppresses the adipogenesis of 3T3-L1 cells via the inhibition of Wnt/beta-catenin signaling. P. hydropiper and isoquercitrin may therefore be potential therapeutic agents for obesity and its associated disorders. Copyright (C) 2011 John Wiley & Sons, Ltd.
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