期刊
PHYTOTHERAPY RESEARCH
卷 26, 期 6, 页码 826-832出版社
WILEY-BLACKWELL
DOI: 10.1002/ptr.3643
关键词
saffron; atrioventricular node; atrial fibrillation; arrhythmia
资金
- Deputy of Research at Golestan University of Medical Sciences
The study assessed the hydroalcohol extract effects of Crocus sativus L. (saffron) on (i) the basic and rate-dependent electrophysiological properties of the AV node, (ii) remodeling of the AV node during experimental atrial fibrillation (AF) and (iii) the role of nitric oxide (NO) in the effects of saffron on the AV node. Stimulation protocols in isolated AV node were used to quantify AV nodal recovery, facilitation and fatigue in four groups of rabbits (n?=?816 per group). In addition, the nodal response to AF was evaluated at multiple cycle lengths and during AF. Saffron had a depressant effect on AV nodal rate-dependent properties; further, it increased Wenckebach block cycle length, functional refractory period, facilitation and fatigue (p?
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