Renoprotective Effect of Tanshinone IIA, An Active Component of Salvia miltiorrhiza, on Rats with Chronic Kidney Disease

Chronic kidney disease (CKD) is a common cause of end-stage renal disease. Antihypertensive agents are used clinically to inhibit the progression of CKD, but cannot prevent eventual renal failure. This study investigated the effect of Tanshinone IIA, an active component of Salvia miltiorrhiza, in rats suffering from CKD induced by 5/6 nephrectomy. After development of renal insufficiency, the rats were treated with Tanshinone IIA (10 mg/kg) for 8 weeks. Serum creatinine, angiotensin II (Ang II), transforming growth factor beta 1 (TGF-beta 1) and collagen IV levels were significantly reduced in Tanshinone HA treated rats compared with a control group. In addition, Tanshinone HA suppressed increases in urinary protein excretion in CKD rats. These findings suggest that chronic oral administration of Tanshinone IIA can improve renal dysfunction associated with CKD. Copyright (C) 2010 John Wiley & Sons, Ltd.