4.7 Article

Oral Administration of Aloe vera and Honey Reduces Walker Tumour Growth by Decreasing Cell Proliferation and Increasing Apoptosis in Tumour Tissue

期刊

PHYTOTHERAPY RESEARCH
卷 25, 期 4, 页码 619-623

出版社

WILEY
DOI: 10.1002/ptr.3293

关键词

Aloe vera; honey; cancer; proliferation; apoptosis

资金

  1. FAPESP (Fundacao de Amparo a Pesquisa do Estado de Sao Paulo) [2006/06007-3, 2006/04645-2]
  2. CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico) [304000/2007-8, 502915/2007-2]
  3. FAPESP, Brazil [2007/05788-4]

向作者/读者索取更多资源

Cancer is diagnosed in approximately 11 million people and is responsible for almost 8 million deaths worldwide every year. Research in cancer control has shown the importance of co-adjuvant therapies. Aloe vera may reduce tumour mass and metastasis rates, while honey may inhibit tumour growth. This study verified the influence of Aloe vera and honey on tumour growth and in the apoptosis process by assessing tumour size, the cell proliferation rate (Ki67-LI) and Bax/Bcl-2 expression at 7, 14 and 20 days after Walker 256 carcinoma implant in Wistar rats distributed into two groups: the WA group - tumour-bearing rats that received a gavage with a 670 mu L/kg dose of Aloe vera and honey solution daily, and the CW group - tumour-bearing rats which received only a 0.9% NaCl solution. The effect of Aloe vera and honey against tumour growth was observed through a decrease in relative weight (%) and Ki67-LI in tumours from the WA group compared with those from the CW group. The Bax/Bcl-2 ratio increased in tumours from the WA group at all tested timepoints. These data suggest Aloe vera and honey can modulate tumour growth by reducing cell proliferation and increasing apoptosis susceptibility. Copyright (C) 2010 John Wiley & Sons, Ltd.

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