期刊
PHYTOTHERAPY RESEARCH
卷 25, 期 1, 页码 74-80出版社
WILEY
DOI: 10.1002/ptr.3223
关键词
Da-Cheng-Qi decoction; rhein; emodin; pharmacokinetics; HPLC; traditional Chinese medicine
资金
- National Natural Science Foundation of China [30400576, 30672588]
Da-Cheng-Qi decoction (DCQD), a traditional Chinese medicine preparation used to treat digestive diseases, is composed of dahuang (Rheum officinale Baill, Polygonaceae), houpu (Magnolia officinalis Rehd., Magnoliaceae), zhishi (Citrus aurantium L, Rutaceae) and mangxiao (sodium sulphate). Rhein and emodin are the major active components of Rheum officinale Baill. To investigate the effects of food and gender on the plasma concentrations of rhein and emodin after oral administration of DCQD, a rapid high-performance liquid chromatographic method was developed and validated. A reversed phase C-18 column (150 x 4.6 mm) and a mobile phase of methanol and 0.2% acetic acid (78: 22, v/v) were employed with ultraviolet detection at 254 nm. Feeding was observed to decrease the absorption of rhein and emodin in rats receiving DCQD orally. No evidence for gender-based differences in the pharmacokinetics of rhein was observed. However, the half-life and area under the concentration-time curve for emodin differed significantly between male and female rats. Because food intake and gender are anticipated to influence the pharmacokinetics of DCQD in human subjects, it is recommended that oral doses of DCQD be reduced in fasting subjects and that female patients receive lower oral doses compared with male patients. Copyright (C) 2010 John Wiley & Sons, Ltd.
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