期刊
PHYTOTHERAPY RESEARCH
卷 25, 期 1, 页码 11-16出版社
WILEY
DOI: 10.1002/ptr.3216
关键词
cancer; Paullinia cupana; cyclin D1; Ehrlich ascites carcinoma; cancer treatment
资金
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [05/54194-4, 2004/07815-0, 2004/14128-0]
The objective of this work is to report the antiproliferative effect of P. cupana treatment in Ehrlich Ascites Carcinoma (EAC)-bearing animals. Female mice were treated with three doses of powdered P. cupana (100, 1000 and 2000 mg/kg) for 7 days, injected with 10(5) EAC cells and treated up to day 21. In addition, a survival experiment was carried out with the same protocol. P. cupana decreased the ascites volume (p = 0.0120), cell number (p = 0.0004) and hemorrhage (p = 0.0054). This occurred through a G1-phase arrest (p < 0.01) induced by a decreased gene expression of Cyclin D1 in EAC cells. Furthermore, P. cupana significantly increased the survival of EAC-bearing animals (p = 0.0012). In conclusion, the P. cupana growth control effect in this model was correlated with a decreased expression of cyclin D1 and a G1 phase arrest. These results reinforce the cancer therapeutic potential of this Brazilian plant. Copyright (C) 2010 John Wiley & Sons, Ltd.
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