期刊
PHYTOTHERAPY RESEARCH
卷 25, 期 4, 页码 615-618出版社
WILEY
DOI: 10.1002/ptr.3342
关键词
20S proteasome inhibitor; Spatholobus suberectus; isoliquiritigenin; genistein; 7-hydroxyflavanone
资金
- Korea Research Foundation [KRF-2007-531-E00113]
- National Research Foundation of Korea [531-2007-1-E00113, 2007-531-E00113] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
The promising biological role of the ubiquitin proteasome pathway (UPP) in cancer therapy has recently emerged. Inhibition of proteasome has been proposed as a new therapeutic target for treatment of cancer. Bioassay-guided fractionation of a MeOH extract of the stems of Spatholobus suberectus resulted in seven compounds, liquiritigenin (1), isoliquiritigenin (2), genistein (3), daidzein (4), medicarpin (5), 7-hydroxyflavanone (6) and formononetin (7), which were evaluated for the first time for their inhibitory effect on 20S proteasome. Among the isolated compounds, 2, 3 and 6 exhibited inhibitory activities on human 20S proteasome with IC50 values of 4.88 +/- 1.5, 9.26 +/- 1.2 and 5.21 +/- 1.5 mu M, respectively. Copyright (C) 2010 John Wiley & Sons, Ltd.
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