期刊
PHYTOTHERAPY RESEARCH
卷 23, 期 2, 页码 220-225出版社
WILEY
DOI: 10.1002/ptr.2593
关键词
obesity; wild ginseng; peroxisome proliferators-activated receptors-gamma; glucose transporter 4; lipoprotein lipase; insulin receptor
资金
- Technology Development Program for Agriculture and Forestry [ARPC 105036-3]
- Ministry of Agriculture and Forestry
- Republic of Korea
The antiobesity effect of wild ginseng (WG; Panax ginseng C.A. Meyer) in male obese leptin-deficient (B6.V-Lepob, 'ob/ob') mice was evaluated. WG was administered orally to mice at doses of 100 mg/kg and 200 mg/kg daily for 4 weeks. The WG-treated ob/ob mice showed a loss of body weight and a decrease in blood glucose levels compared with control mice. WG regulated the mRNA expression level especially, it increased peroxisome proliferators-activated receptors-gamma (PPAR-gamma) and lipoprotein lipase (LPL) in adipose tissue, as well as glucose transporter 4 (GLUT4) and insulin receptor (IR) in the skeletal muscle and liver. Taken together, these results suggest that WG may play a vital role in the antiobesity effect in ob/ob mice; this has importance in insulin sensitivity. This may prove to be of clinical importance in improving the management of obesity and related metabolic syndromes. Copyright (C) 2008 John Wiley & Sons, Ltd.
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