期刊
PHYTOTHERAPY RESEARCH
卷 24, 期 6, 页码 821-826出版社
WILEY-BLACKWELL
DOI: 10.1002/ptr.3022
关键词
Veratrum dahuricum; steroidal alkaloid; antitumor; antiplatelet; hedgehog
资金
- program for Changjiang Scholars and Innovative Research Team in University (PCSIRT)
- NCET Foundation
- NSFC [30725045]
- National 863 Program [2006AA02Z338]
- China Postdoctoral Science Foundation [20070410711]
- '973' program of China [2007CB507400]
- Shanghai Leading Academic Discipline [B906]
- Scientific Foundation of Shanghai China [07DZ19728, 06DZ19717, 06DZ19005]
Ten steroidal alkaloids cyclopamine, veratramine, jervine, 3, 15-diangyloylgermine, 3-angyloylzygadenine, 3-veratroyl zygadenine, 15-veratroylgermine, germine, veratrosine and pseudojervine - from Veratrum dahuricum, together with the ethanol extract and total alkaloids, were evaluated for their antitumor and antiplatelet activities. Cyclopamine, veratramine and germine significantly inhibited the hedgehog pathway in NIH/3T3 cells. Cyclopamine exerted a potent inhibitory effect against the growth of PANC-1 tumors in mice, with inhibition rates of 40.64%, 44.37%, 46.77% at doses of 5.0, 15.0 and 50.0 mg kg-1, respectively. Veratroylgermine was found to produce the strongest inhibition against the platelet aggregation induced by arachidonic acid, with inhibition rate of 92.0% at 100 mu M. Copyright (C) 2009 John Wiley & Sons, Ltd.
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