期刊
PHYTOTHERAPY RESEARCH
卷 22, 期 2, 页码 254-255出版社
JOHN WILEY & SONS LTD
DOI: 10.1002/ptr.2254
关键词
Cassia siamea; in vitro antiplasmodial assay; lupeol; emodin
Cassia siamea L. (Fabaceae) was identified from the southwest Nigerian ethnobotany as a remedy for febrile illness. This led to the bioassay-guided fractionation of stem bark of the plant extract, using the parasite lactate dehydrogenase assay and multi-resistant strain of Plasmodium falciparum (K1) for assessing the in vitro antimalarial activity. Emodin and lupeol were isolated from the ethyl acetate fraction by a combination of chromatographic techniques. The structures of the compounds were determined by spectroscopy, co-spotting with authentic samples and comparison with literature data. Both compounds were found to be the active principles responsible for the antiplasmodial property with IC50 values of 5 mu g/mL, respectively. Copyright (C) 2007 John Wiley & Sons, Ltd.
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