期刊
PHYTOMEDICINE
卷 19, 期 3-4, 页码 364-368出版社
ELSEVIER GMBH, URBAN & FISCHER VERLAG
DOI: 10.1016/j.phymed.2011.10.011
关键词
Curcuma wenyujin; Chaetomium globosum L18; Endophytic fungi; Metabolites; Antifungal activity; Cytotoxic activity
资金
- Scientific Research Starting Foundation of Jilin Agricultural University [201110]
- Scientific and Technological Planning of Zhejiang province, China [2005C13019]
- Department of Pharmacology, Wenzhou Medical College
- College of Agronomy in Jilin Agriculture University
An endophytic fungus, strain L18, isolated from the medicinal plant Curcuma wenyujin Y.H. Chen et C. Ling was identified as Chaetomium globosum Kunze based on morphological characteristics and sequence data for the internal transcribed spacer (ITS-5.8S-ITS2) of the nuclear ribosomal DNA. A new metabolite named chaetoglobosin X (1), together with three known compounds erogosterol (2), ergosterol 5 alpha,8-peroside (3) and 2-methyl-3-hydroxy indole (4), were isolated from C. globosum L18. Their structures were elucidated by spectroscopic methods including NMR, UV, IR and MS data and comparison with published data. Chaetoglobosin X (1) is hitherto unknown, whereas 2-methyl-3-hydroxy indole (4) is reported for the first time as a fungal metabolite, and erogosterol (2) and ergosterol 5 alpha,8-peroside (3) are known fungal metabolites previously identified in other genera. Chaetoglobosin X (1) exhibited a broader antifungal spectrum and showed the strongest cytotoxic activity against H22 and MFC cancer cell lines. (C) 2011 Elsevier GmbH. All rights reserved.
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