Anti-osteoporotic constituents from Indian medicinal plants

The objective of this study was to determine the in vitro osteogenic activities of selected medicinal plants used traditionally in India The compounds isolated from three plants viz Allophylus serratus Cissus quad rangularis and Vitex negundo were evaluated for their in vitro osteogenic activities Primary cultures of osteoblasts were used to determine the effects of these components on osteoblast functions Five (4 6 9 12 and 14) of the fourteen compounds isolated led to increase in osteoblast differentiation and mineralization These findings lend support to the use of Allophylus serratus Cissus quadrangularis and Vitex negundo in traditional medicine (C) 2010 Elsevier GmbH All rights reserved