期刊
PHYTOMEDICINE
卷 15, 期 6-7, 页码 470-477出版社
ELSEVIER GMBH
DOI: 10.1016/j.phymed.2007.11.010
关键词
D-galactosamine; Fumaria indica; hepatoprotective; protopine
资金
- CSIR, New Delhi
The present investigation demonstrates the hepatoprotective potential of 50% ethanolic water extract of whole plant of Fumaria indica and its three fractions viz., hexane, chloroform and butanol against D-galactosamine induced hepatotoxicity in rats. The hepatoprotection was assessed in terms reduction in histological damage, changes in serum enzymes (SGOT, SGPT, ALP) and metabolites bilirubin, reduced glutathione (GSH) and lipid peroxidation (MDA content). Among fractions more than 90% protection was found with butanol fraction in which alkaloid protopine was quantified as highest i.e. about 0.2 mg/g by HPTLC. The isolated protopine in doses of 10-20 mg p.o. also proved equally effective hepatoprotectants as standard drug silymarine (single dose 25 mg p.o.). In general all treatments excluding hexane fraction proved hepatoprotective at par with silymarine (P <= 0.01). (c) 2007 Elsevier GmbH. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据