期刊
PHYTOCHEMISTRY LETTERS
卷 9, 期 -, 页码 46-50出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.phytol.2014.04.009
关键词
Sesquiterpene coumarins; Ferula narthex Boiss; Antileishmanial
资金
- Pakistan Academy of Sciences and Education and Literacy Department, Govt. of Sindh [5-9/PAS/2592]
Two new sesquiterpene coumarins, fnarthexone (1) and fnarthexol (2), along with three known coumarin derivatives, conferol (3), conferone (4) and umbelliferone (5), were isolated from the plant Ferula narthex Boiss. The structures of the compounds 1-5 were elucidated using modern spectroscopic techniques. The structure of compound 3 was unambiguously deduced by the single-crystal X-ray diffraction technique. Compounds 1-4 were tested for in vitro leishmanicidal activity and promising results were obtained. Conferol (3) was found to be the most potent with IC50 value of 11.51 +/- 0.09 mu g/mL. (C) 2014 Phytochemical Society of Europe. Published by Elsevier B. V. All rights reserved.
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