Chemical constituents of Heracleum dissectum and their cytotoxic activity

A new phenylpropanoid, 3-O-(6-O-beta-D-xylopyranosyloxy-beta-D-glucopyranosyl)-4-hydroxy-1-allylbenzene (1) and a new neolignan glycoside, (7S, 8R)-dehydrodiconiferyl alcohol 4-O-beta-D-glucopyranoside-9'-n-butanol ether (2), together with 2 known neolignans (3-4) and 5 known coumarins (5-9) were isolated from the roots of Heracleum dissectum Ledeb. Their structures were elucidated by means of various spectroscopic analyses. Five of the isolated compounds were tested against Hela, HCT-8, and HepG2 cancer cell lines and showed moderate cytotoxic activities with IC50 values between 5.8 and 18.6 mu M. (C) 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.