Enantiomeric chromones from Harrisonia perforata

Six new chromones (1-3 and 7-9), along with 10 known ones, were isolated from the ethanol extract of Harrisonia perforata. The structures of the new compounds were elucidated by extensive spectroscopic and single crystal X-ray diffraction analyses. Compounds 1-3 and 8-9 are all racemates, and the corresponding enantiomers [(+)-1/2/3/8/9 and (-)-1/2/3/8/9] were obtained by chiral HPLC separation, respectively. The absolute configuration of (+)- 1 was deduced by Mosher's method. Crown Copyright (C) 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.