期刊
PHYTOCHEMISTRY LETTERS
卷 7, 期 -, 页码 89-92出版社
ELSEVIER
DOI: 10.1016/j.phytol.2013.10.007
关键词
Ranunculaceae; Coptis chinensis; Isoquinoline alkaloid
资金
- National Natural Science Foundation of China [81273391, 81273562]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT0965]
- Ministry of Science and Technology of China [2013BAI11B05, 2013DFM30080]
- China Postdoctoral Science Foundation [201104369]
A pair of new enantiomeric isoquinoline alkaloids, (+)-and (-)-5-hydroxyl-8-oxyberberine (1), along with nine known analogs (2-10) were isolated from the rhizoma of Coptis chinensis. Their structures with absolute configurations were elucidated on the basis of spectroscopic methods, X-ray diffraction analysis, and quantum chemical calculation. The antibacterial activities of 1-10 were also evaluated. Berberine (8) displayed synergism against methicillin-resistant Staphylococcus aureus (MRSA) in combination with ceftazidime and cefepiem. (C) 2013 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
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