期刊
PHYTOCHEMISTRY LETTERS
卷 6, 期 4, 页码 620-624出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.phytol.2013.08.002
关键词
20(R)-ginsenoside Rf; 20(S)-Ginsenoside Rf; Epimerization; Chemical profile; Panax ginseng; Red ginseng
资金
- Chungnam National University
In spite of the general concept that herbal supplements are safe, there is a lack of appropriate quality control measures and regulations that often culminates in serious undesirable effects such as allergic reactions and renal and liver damage. Thus, there is a growing need to establish a suitable methodology that enables authentication and quality assurance of herbal products. The root of Panax ginseng C. A. Meyer (Araliaceae), commonly called ginseng, is traditionally recognized as a prominent herbal medicine in Far East Asia. There are two types of processed ginseng, white and red ginseng, based on processing methods, and these play a significant role in modifying ginsenosides, which are the major bioactive metabolites in these products. Herein we purify and characterize a new ginsenoside, 20(R)-ginsenoside Rf, utilizing NMR, UPLC-ESI-Q-TOF-MS and validate the metabolite is generated from its epimer, 20(S)-ginsenoside Rf during the steaming process to manufacture red ginseng. We further propose a relevant mechanism for the chemical conversion. This finding updates chemical profiling of ginseng products that can be employed in quality assurance and authentication. (C) 2013 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
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