Anthraquinone derivatives from the mangrove-derived fungus Phomopsis sp PSU-MA214

One new tetrahydroanthraquinone derivative, (2R,3S)-7-ethyl-1,2,3,4-tetrahydro-2,3,8-trihydroxy-6-methoxy- 3-methyl-9,10-anthracenedione (1), together with five known anthraquinones (2-6), two known phenylethyl alcohols (7-8) and one known butanamide (9), were isolated from the mangrove-derived fungus Phomopsis sp. PSU-MA214. Their structures were established by spectroscopic evidence. Compound 1 is a rare ethyltetrahydroanthraquinone and exhibited weak cytotoxicity against breast cancer (MCF-7) cell lines and antibacterial activity against the standard Staphylococcus aureus ATCC25923 and methicillin-resistant S. aureus SK1. (C) 2012 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.