期刊
PHYTOCHEMISTRY LETTERS
卷 5, 期 2, 页码 401-406出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.phytol.2012.03.013
关键词
Erythroxylum suberosum; Erythroxylaceae; Diterpenes; Artemia salina; Flavonoid glycosides
资金
- FUNDECT-MS and CPq-PROPP-UFMS
- CAPES
- CNPq
Bioassay-guided fractionation of the ethanol extract from the branches of Erythroxylum suberosum, which was toxic to brine shrimp larvae, afforded five diterpenes bearing abietane and ent-kaurane-type skeletons from an active fraction. From these, four were new, 7-oxo-16-hydroxy-abiet-15(17)-en-19-al, 16-hydroxyabiet-15(17)-en-7-one, 7 alpha,16-dihydroxy-abiet-15(17)-en-19-al and ent-12 alpha-hydroxy-kaur-16-en-19-al, while methyl ent-7 alpha,15 beta-dihydroxy-kaur-16-en-19-oate is reported for the first time as a natural product. This is also the first reported occurrence of abietane-type diterpenes in the genus Erythroxylum. The flavonoid ombuin-3-rutinoside was isolated from an inactive fraction, while rutin (quercetin-3-rutinoside) was obtained from the non-toxic ethanol extract of the leaves. The structures of the new and known compounds were established by analyses of 1D-and 2D-NMR and mass spectrometry data. (C) 2012 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
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