期刊
PHYTOCHEMISTRY LETTERS
卷 2, 期 4, 页码 159-162出版社
ELSEVIER
DOI: 10.1016/j.phytol.2009.05.006
关键词
Pistacia atlantica; Anacardiaceae; HPLC activity profiling; Antiplasmodial activity; Flavonoid
资金
- Swiss National Science Foundation [316000-113109]
- National Science Foundation [316000-113109]
- Steinegg-Foundation
- Hans und Wilma Stutz-Foundation
- Herisau, and the Fonds fur Lehre und Forschung, Basel
In the course of a medium throughput screen of 640 plant extracts for antimalarial activity an ethyl acetate extract of Pistacia atlantica DC. (Anacardiaceae) was found to be active. With analytical scale time-based HPLC separation and testing for antiplasmodial activity in combination with hyphenated methods (HPLC-PDA, -MSn, HR-MS, off line microprobe NMR) the active substance was identified. Subsequent isolation and structure elucidation yielded flavone 3-methoxycarpachromene. It had an IC50 of 3.4 mu M towards Plasmodium falciparum K1 strain. (C) 2009 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
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