期刊
PHYTOCHEMISTRY
卷 151, 期 -, 页码 61-68出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2018.04.005
关键词
Sinocalycanthus chinensis; Calycanthaceae; Endangered plant; Chimonanthine-type alkaloids; Cytotoxicity
资金
- NSFC [81773599, 21472021, 81273401]
- STCSM [17430742200]
Two previously undescribed chimonanthine-type [sinodamines A and B] and five related known dimeric tryptamine-derived alkaloids were isolated and characterized from the leaves of the endangered ornamental plant Sinocalycanthus chinensis under the guidance of LC-MS detection and dereplication analyses, along with conventional isolation procedures. Their structures were established on the basis of spectroscopic methods and chemical transformations. Sinodamine A can be regarded as the naturally occurring N-oxide derivative of its pseudo-mesomer sinodamine B. An acid-catalyzed Meisenheimer rearrangement from sinodamine A to its oxazine-form with a final equilibrium of 1:2 was observed by monitoring their NMR spectra. (-)-Folicanthine showed significant cytotoxicity against human lung carcinoma A549 and colorectal carcinoma HT29 cells, with IC50 values of 7.76 and 6.16 mu M, respectively. (C) 2018 Elsevier Ltd. All rights reserved.
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