期刊
PHYTOCHEMISTRY
卷 146, 期 -, 页码 8-15出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2017.11.011
关键词
Talaromyces amestolkiae; Trichocomaceae; Meroterpenoids; Mangrove endophytic fungus; Anti-inflammatory activity
资金
- National Natural Science Foundation of China [21472251, 41276146, 41404134]
- Science & Technology Plan Project of Guangdong Province of China [2013B021100011]
- Key project of Natural Science Foundation of Guangdong Province [2016A040403091]
- Special Financial Fund of Innovative Development of Marine Economic Demonstration Project [GD2012-D01-001]
Four previously undescribed meroterpenoids, amestolkolides A-D, along with three known compounds were isolated from the mangrove endophytic fungus Talaromyces amestolkiae YX1 cultured on wheat solid-substrate medium culture. Their structures were elucidated by a combination of spectroscopic analyses. The absolute configurations of amestolkolides B and C, and purpurogenolide E were determined by single-crystal X-ray diffraction using Cu K alpha radiation, and those of amestolkolides A and D were elucidated on the basis of experimental and calculated electronic circular dichroism spectra. The absolute configuration of amestolkolides A-D, and purpurogenolide E (9R) at C-9 was different from that of analogues (9S) in references, so that their plausible and distinct biosynthetic pathways were proposed. Amestolkolide B showed strong anti-inflammatory activity in vitro by inhibiting nitric oxide (NO) production in lipopolysaccharide activated in RAW264.7 cells with IC50 value of 1.6 +/- 0.1 mu M. (C) 2017 Elsevier Ltd. All rights reserved.
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