期刊
PHYTOCHEMISTRY
卷 108, 期 -, 页码 177-188出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2014.08.029
关键词
Salvia viridis L.; Lamiaceae; Lupane; Triterpenoid; Diterpenoid; Abietane; Phenylpropanoid; Verbascoside; Flavonoid; Antibacterial activity
资金
- Royal Thai government
Three diterpenoids, 1-oxomicrostegiol (1), viroxocin (2), viridoquinone (3), were isolated from the roots of Salvia viridis L. cvar. Blue Jeans. Five known diterpenoids, microstegiol (4), 7 alpha-acetoxy-14-hydroxy-8,13-abietadiene-11,12-dione (5; 7-O-acetylhorminone tautomer), 7 alpha,14-dihydroni-8,13-abietadiene-11,12-dione (6; horminone tautomer), ferruginol and salvinolonyl 12-methyl ether (7) were also found in the roots together with 1-docosyl ferulate (8), and a mixture of 2-(4'-alkoxyphenyl) ethyl alkanoates (9). Two lupane triterpenoids, 2 alpha-acetoxy-lup-20(29)-en-3 beta-ol (10), and 3 beta-acetoxy-lup-20(29)-en-2 alpha-ol (11) were found in the aerial parts together with known compounds, lup-20(29)-ene-2 alpha,3 beta-diol (12), ursolic acid, oleanolic acid, beta-sitosterol and beta-sitosterol glucoside. A known phenylpropanoid, trans-verbascoside (or acteoside; 13), was the main constituent in the polar fraction of the aerial part, and it is now reported in the genus Salvia for the first time. Other polyphenolic compounds were cis-verbascoside (14), leucosceptoside A (15), martynoside (16), caffeic acid, 6-O-caffeoyl-glucose (18), rosmarinic acid, salidroside, luteolin-7-O-alpha-rhamnopyranosyl-(1 -> 6)-beta-galactopyranoside, luteolin-7-O-beta-galactopyranoside, luteolin-7-O-alpha-rhamnopyranosyl-(1 -> 6)-beta-glucopyranoside, luteolin-7-O-beta-glucopyranoside, and apigenin-7-O-alpha-glucopyranoside. The structures were determined by 1D-, 2D-NMR and HR-ESI-MS techniques. Compounds 6, 10, ferruginol, ursolic acid and oleanolic acid exhibited antibacterial activity against Entero coccus faecalis (ATCC 775) with MIC 50 mu M, 25 mu M, 50 mu M, 12.5 mu M, 12.5 mu M respectively. Ferruginol, ursolic acid and oleanolic acid were also active against Staphylococcus aureus (ATCC 6571), and Bacillus cereus (ATCC 2599) with MIC 12.5-50 mu M. 4 was also active against S. aureus (ATCC 6571) with MIC 50 mu M. These values are consistent with previous studies on the antimicrobial activity of Salvia diterpenoids. (c) 2014 Elsevier Ltd. All rights reserved.
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