期刊
PHYTOCHEMISTRY
卷 98, 期 -, 页码 174-182出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2013.11.006
关键词
Cipadessa baccifera; Limonoids; Cytotoxic activity; Cancer cell lines
资金
- Council of Scientific and Industrial Research, New Delhi (India) under CSIR-Network program [CSC-0130]
- UGC
- CSIR
Six new methyl angolensate type (1-6) and three new mexicanolide-type (7-9) limonoids, along with six known limonoids (10-15), were isolated from the seeds of Cipadessa baccifera. The structures of all these compounds were established by extensive 1D, 2D NMR, and HRESIMS experiments, and structures of 11 and 13 were further confirmed by a single crystal X-ray diffraction analysis, which are reported for the first time. The cytotoxic activities of these isolates were also studied against A549, MCF7, ME-180, HT-29, B-16, ACHN cancer cell lines using MIT assay, and results indicated that compounds 4,10, and 14 displayed potent cytotoxic activity against B-16, ACHN cell lines with an IC50 values of 8.51 and 7.0 mu g/mL, respectively. (C) 2013 Elsevier Ltd. All rights reserved.
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