期刊
PHYTOCHEMISTRY
卷 85, 期 -, 页码 185-193出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2012.08.015
关键词
Valeriana jatamansi; Valerianaceae; Chlorinated valepotriates; Dereplication; Cytotoxicity
资金
- NCET Foundation
- NSFC [30725045]
- Global Research Network for Medicinal Plants (GRNMP)
- King Saud University
- Shanghai Leading Academic Discipline Project [B906]
- FP7- PEOPLE-IRSES (TCMCANCER Project) [230232]
- Key laboratory of drug research for special environments
- PLA
- Shanghai Engineering Research Center for the Preparation of Bioactive Natural Products [10DZ2251300]
- Scientific Foundation of Shanghai China [09DZ1975700, 09DZ1971500, 10DZ1971700]
HPLC-PDA-MS and TLC analysis were used to look for minor cytotoxic chlorinated valepotriates from whole plants of Valeriana jatamansi (syn. Valeriana wallichii DC.). This resulted in isolation of 15 chlorinated valepotriates, designated as chlorovaltrates A-O, together with six known analogues, (15,3R,5R,7S,8S,9S)-3,8-epoxy-1,5-dihydroxyvalechlorine, volvaltrate B, chlorovaltrate, rupesin B, (15,3R,5R,7S,8S,95)-3,8-epoxy-1-O-ethyl-5-hydroxyvalechlorine, and (1R,3R,5R,7S,8S,9S)-3,8-epoxy-1-O-ethyl-5-hydroxyvalechlorine. Their structures were elucidated by spectroscopic methods including homo- and heteronuclear two-dimensional NMR experiments. Chlorovaltrates K-N, chlorovaltrate and rupesin B showed moderate cytotoxicity against lung adenocarcinoma (A 549), metastatic prostate cancer (PC-3M), colon cancer (HCT-8) and hepatoma (Bel 7402) cell lines with IC50 values of 0.89-9.76 mu M. (C) 2012 Elsevier Ltd. All rights reserved.
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