期刊
PHYTOCHEMISTRY
卷 96, 期 -, 页码 389-396出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2013.10.002
关键词
Mitragyna diversifolia; Rubiaceae; Indole alkaloids; Acetylcholinesterase inhibition
资金
- National Science Foundation of China [21272275, 81173526]
- Program for Changjiang Scholars and Innovative Research Team in University [PCSIRT-IRT1193]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
- Program for New Century Excellent Talents in University, State Education Ministry of China [NCET-11-0738]
Five monoterpene indole alkaloids, mitradiversifoline, with a unique rearranged skeleton, specionoxeine-N(4)-oxide, 7-hydroxyisopaynantheine, 3-dehydropaynantheine, and 3-isopaynantheine-N(4)-oxide, and 10 known ones, were isolated from Mitragyna diversifolia. All the isolates were evaluated for their inhibition of acetylcholinesterase activities, and four showed moderate activities, with IC50 values of 4.1, 5.2, 10.2, and 10.3 mu M, respectively. (C) 2013 Elsevier Ltd. All rights reserved.
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