期刊
PHYTOCHEMISTRY
卷 80, 期 -, 页码 37-41出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2012.05.014
关键词
Portulaca oleracea; Portulacaceae; Homoisoflavonoid; Portulacanone; Cytotoxic activity
资金
- Chinese Academy of Sciences [KSCX2-YW-N-0804, KSCX2-EW-J-28]
- National Natural Science Foundation of China [30870248, 30900125]
- Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, CAS [200920]
- SRF
Four homoisoflavonoids named portulacanones A-D, identified as 2'-hydroxy-5,7-dimethoxy-3-benzyl-chroman-4-one, 2'-hydroxy-5,6,7-trimethoxy-3-benzyl-chroman-4-one, 5,2'-dihydroxy-6,7-dimethoxy-3-benzyl-chroman-4-one, and 5,2'-dihydroxy-7-methoxy-3-benzylidene-chroman-4-one, were isolated from aerial parts of the plant Portulaca oleracea along with nine other known metabolites. Their structures were established on the basis of extensive spectroscopic analyses. Portulacanones A-D is the first group of homoisoflavonoids so far reported from the family Portulacaceae. They represent a rare subclass of homoisoflavonoids in nature with a structural feature of a single hydroxyl group substituted at C-2' rather than at C-4' in ring B of the skeleton. Three homoisoflavonoids and the known compound 2,2'-dihydroxy-4',6'-dimethoxychalcone selectively showed in vitro cytotoxic activities towards four human cancer cell lines. Especially 2,2'-dihydroxy-4',6'-dimethoxychalcone showed cytotoxic activity against cell line SGC-7901 with an IC50 value of 1.6 mu g/ml, which was more potent than the reference compound mitomycin C (IC50 13.0 mu g/ml). (C) 2012 Elsevier Ltd. All rights reserved.
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