期刊
PHYTOCHEMISTRY
卷 76, 期 -, 页码 60-72出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2011.12.010
关键词
Glycyrrhiza glabra L.; Glycyrrhiza inflata L.; Glycyrrhiza echinata L.; Glycyrrhiza uralensis L.; NMR-based metabolomics; GC-MS; LC-MS; Glycyrrhizin; Licochalcone A; Principal component analysis; Anticancer activity; Licorice; Liquorice
资金
- Alexander von Humboldt-foundation, Germany
Glycyrrhiza glabra, commonly known as licorice, is a popular herbal supplement used for the treatment of chronic inflammatory conditions and possesses anticancer and antiviral activities. This species contains a plethora of phytochemicals including terpenoids, saponins, flavonoids, polyamines and polysaccharides. The full complement of bioactive compounds has yet to be elucidated, a step necessary in order to explain its medicinal use. There are over 30 species in the Glycyrrhiza genus world-wide, most of which have been little characterized in terms of phytochemical or pharmacological properties. Here, large scale multi-targeted metabolic profiling and fingerprinting techniques were utilized to help gain a broader insight into Glycyrrhiza species chemical composition. UV, MS and NMR spectra of extracted components were connected with NMR, MS, and multivariate analyses data from Glycyrrhiza glabra, Glycyrrhiza uralensis, Glycyrrhiza inflate and Glycyrrhiza echinata. Major peaks in H-1 NMR and MS spectra contributing to the discrimination among species were assigned as those of glycyrrhizin, 4-hydroxyphenyl acetic acid, and glycosidic conjugates of liquiritigenin/isoliquiritigenin. Primary metabolites profiling using GC-MS revealed the presence of cadaverine, an amino acid, exclusively found in G. inflate roots. Both LC-MS and NMR were found effective techniques in sample classification based on genetic and or geographical origin as revealed from derived PCA analysis. (C) 2011 Elsevier Ltd. All rights reserved.
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