2-(2-Phenylethyl)chromones from Chinese eaglewood

2-(2-Phenylethyl) chromones and a 2-(2-phenylethenyl) chromone, were isolated from the ethanolic extract of Chinese eaglewood. Their structures were determined on the basis of extensive analyses of spectroscopic data. Among those, one showed significant neuroprotective activities against both glutamate-induced and corticosterone-induced neurotoxicity in P12 pheochromocytoma and human U251 glioma cells at a concentration of 10 mu M and increased cell viability by 82.2% and 86.9%, respectively. (C) 2011 Elsevier Ltd. All rights reserved.