期刊
PHYTOCHEMISTRY
卷 74, 期 -, 页码 140-145出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2011.11.002
关键词
Ervatamia chinensis; Apocynaceae; Bisindole alkaloids; Ervachinines A-D; Cytotoxicity
资金
- National Basic Research Program of China (973 Program) [2009CB940900, 2009CB522300]
- National Natural Science Foundation of China [31100259, 30830114]
- Young Academic and Technical Leader Raising Foundation of Yunnan Province [20090072]
Four vobasinyl-ibogan type bisindole alkaloids, ervachinines A-D (1-4), along with 12 known terpenoid indole alkaloids, were isolated from the whole plant of Ervatamia chinensis. Their structures were elucidated by analysis of spectroscopic data, including 1D and 2D NMR, and the absolute configurations of 1-4 were determined by CD exciton chirality method. All of the compounds were evaluated for in vitro cytotoxicity against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480. Bisindole alkaloids 1-6 exhibited inhibitory effects, with IC50 values comparable to those of cisplatin. (C) 2011 Elsevier Ltd. All rights reserved.
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