期刊
PHYTOCHEMISTRY
卷 82, 期 -, 页码 118-127出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2012.06.014
关键词
Engelhardia roxburghiana; Juglandaceae; Stem; Diarylheptanoid; Naphthoquinone dimer; Tetralone; Antitubercular activity
资金
- National Science Council (NSC, Taiwan)
- Kaohsiung Medical University Research Foundation [KMUER013]
Bioassay-guided fractionation of stems of Engelhardia roxburghiana led to isolation of: four diarylheptanoids. engelheptanoxides A-D (1-4); two cyclic diarylheptanoids, engelhardiols A (5) and B (6); one naphthoquinone dimer, engelharquinonol (7); and one 1-tetralone, (4S)-4,6-dihydroxy-1-tetralone (8), along with 24 known compounds (9-32). The structures of 1-8 were by spectroscopic analysis. Compounds 5, 6, 13, 22, and 23 showed antitubercular activity against Mycobacterium tuberculosis H(37)Rv with MIC values of 72.7, 62.1, 9.1, 15.3, and 70.1 mu M, respectively. (C) 2012 Elsevier Ltd. All rights reserved.
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