Chlorantholides A-F, eudesmane-type sesquiterpene lactones from Chloranthus elatior

Six eudesmane-type sesquiterpene lactones, named chlorantholides A-F, were isolated from the ethanol extract of Chloranthus elatior (Chloranthaceae) together with 12 known compounds. Their structures were elucidated on the basis of extensive spectroscopic analysis, and their absolute configurations were studied by the CD exciton chirality method. The structure of a recently reported eudesmanolide from Chloranthus anhuiensis: 8 beta-hydroxy-1-oxoeudesma-3,7(11)-dien-12,8-olide, was also revised as 8 beta-hydroxy-2-oxoeudesma-3,7(11)-dien-12,8-olide (chlorantholide D). (C) 2012 Elsevier Ltd. All rights reserved.