期刊
PHYTOCHEMISTRY
卷 81, 期 -, 页码 117-125出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2012.06.005
关键词
Pterospermum acerifolium; Acylated phytosterol glucoside; Phytoceramides; Osteogenic activity; Osteoblast
资金
- Indian Council of Medical Research, New Delhi, India
Phytochemical investigation of seed coats of Pterospermum acerifolium afforded two phytoceramides (1, 2) and two acylated phytosterol glucosides (3, 4) together with five known compounds (5-9). Their structures were elucidated on the basis of extensive spectroscopic analysis using 1D, 2D NMR and Mass spectrometry. Compounds 1, 2, 3, and 4 were assessed for their osteogenic activity using primary cultures of osteoblasts harvested from neonatal rat calvaria. Among these compounds, 1 and 2 markedly stimulated osteoblast differentiation assessed by alkaline phosphatase production and osteoblast mineralization by alizarin red-S staining. (C) 2012 Elsevier Ltd. All rights reserved.
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