期刊
PHYTOCHEMISTRY
卷 72, 期 17, 页码 2212-2218出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2011.08.001
关键词
Apocynaceae; Alstonia angustiloba; Alkaloids; Bisindole; NMR; Cytotoxicity
资金
- University of Malaya
- MOHE Malaysia
A total of 20 alkaloids were isolated from the leaf and stem-bark extracts of Alstonia angustiloba, of which two are hitherto unknown. One is an alkaloid of the angustilobine type (angustilobine C), while the other is a bisindole alkaloid angustiphylline, derived from the union of uleine and secovallesamine moieties. The structures of these alkaloids were established using NMR and MS analysis. Angustilobine C showed moderate cytotoxicity towards KB cells. (C) 2011 Elsevier Ltd. All rights reserved.
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