期刊
PHYTOCHEMISTRY
卷 72, 期 2-3, 页码 242-247出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2010.11.025
关键词
Aquilaria sinensis; Thymelaeaceae; alpha-Glucosidase inhibitors; Benzophenone glycoside; Flavonoid glucuronide; Xanthone glycoside
资金
- National High Technology Research and Development Program of China [2006BAI 06A01-02]
Eight alpha-glucosidase inhibitors including four new compounds were isolated from the 70% aqueous ethanolic extract of leaves of Aquilaria sinensis (Lour.) Gilg by activity-directed fractionation and purification processes. The ethanolic extract was first separated into petroleum ether, ethyl acetate, n-butanol and water soluble fractions and screened for inhibitory activity against alpha-glucosidase. Further activity-directed investigation lead to the isolation of four new compounds with moderate inhibitory activity, viz, aquilarisinin (1), aquilarisin (2), hypolaetin 5-O-beta-D-glucuronopyranoside (3) and aquilarixanthone (4) from the n-butanol fraction, and four known compounds showing potent activity including mangiferin (5), iriflophenone 2-O-alpha-L-rhamnopyranoside (6), iriflophenone 3-C-beta-D-glucoside (7) and iriflophenone 3,5-C-beta-D-diglucopyranoside (8) from the most potent ethyl acetate fraction. The structures of these compounds were determined by extensive spectroscopic analyses, including IR. UV, ESIMS, HRESIMS, 1D and 2D NMR. (C) 2011 Published by Elsevier Ltd.
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